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Title:

Isolation and functional characterization of hepatitis B virus-specific T-cell receptors as new tools for experimental and clinical use.

Document type:
Journal Article; Article
Author(s):
Wisskirchen, Karin; Metzger, Kai; Schreiber, Sophia; Asen, Theresa; Weigand, Luise; Dargel, Christina; Witter, Klaus; Kieback, Elisa; Sprinzl, Martin F; Uckert, Wolfgang; Schiemann, Matthias; Busch, Dirk H; Krackhardt, Angela M; Protzer, Ulrike
Abstract:
T-cell therapy of chronic hepatitis B is a novel approach to restore antiviral T-cell immunity and cure the infection. We aimed at identifying T-cell receptors (TCR) with high functional avidity that have the potential to be used for adoptive T-cell therapy. To this end, we cloned HLA-A*02-restricted, hepatitis B virus (HBV)-specific T cells from patients with acute or resolved HBV infection. We isolated 11 envelope- or core-specific TCRs and evaluated them in comprehensive functional analyses....     »
Journal title abbreviation:
PLoS ONE
Year:
2017
Journal volume:
12
Journal issue:
8
Pages contribution:
e0182936
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0182936
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28792537
Print-ISSN:
1932-6203
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Virologie
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