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Titel:

Cytomegalovirus vector expressing RAE-1? induces enhanced anti-tumor capacity of murine CD8 T cells.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Tr?an, Tihana; Vukovi?, Kristina; Filipovi?, Petra; Brizi?, Ana Lesac; Lemmermann, Niels A W; Schober, Kilian; Busch, Dirk H; Britt, William J; Messerle, Martin; Krmpoti?, Astrid; Jonji?, Stipan
Abstract:
Designing CD8 T-cell vaccines, which would provide protection against tumors is still considered a great challenge in immunotherapy. Here we show the robust potential of cytomegalovirus (CMV) vector expressing the NKG2D ligand RAE-1? as CD8 T cell-based vaccine against malignant tumors. Immunization with the CMV vector expressing RAE-1?, delayed tumor growth or even provided complete protection against tumor challenge in both prophylactic and therapeutic settings. Moreover, a potent tumor contro...     »
Zeitschriftentitel:
Eur J Immunol
Jahr:
2017
Band / Volume:
47
Heft / Issue:
8
Seitenangaben Beitrag:
1354-1367
Sprache:
eng
Volltext / DOI:
doi:10.1002/eji.201746964
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28612942
Print-ISSN:
0014-2980
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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