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Title:

Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro.

Document type:
Journal Article
Author(s):
Xia, Yuchen; Cheng, Xiaoming; Blossey, Christoph K; Wisskirchen, Karin; Esser, Knud; Protzer, Ulrike
Abstract:
Interferon- (IFN-) has been used for more than 20 years as the first-line therapy for hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, because it has a number of antiviral effects. In this study, we describe a novel mode of its antiviral action. We demonstrate that the supernatant from IFN--treated cultured cells restricted HBV and HCV infection by inhibiting viral entry into hepatoma cells. The factors contained in the supernatant competed with the virus for binding to heparan gly...     »
Journal title abbreviation:
J Immunol Res
Year:
2017
Journal volume:
2017
Pages contribution:
4828936
Language:
eng
Fulltext / DOI:
doi:10.1155/2017/4828936
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28367455
Print-ISSN:
2314-8861
TUM Institution:
Institut für Virologie
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