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Title:

Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma.

Document type:
Journal Article
Author(s):
Garnelo, Marta; Tan, Alex; Her, Zhisheng; Yeong, Joe; Lim, Chun Jye; Chen, Jinmiao; Lim, Kiat Hon; Weber, Achim; Chow, Pierce; Chung, Alexander; Ooi, London Lucien Pj; Toh, Han Chong; Heikenwälder, Mathias; Ng, Irene O L; Nardin, Alessandra; Chen, Qingfeng; Abastado, Jean-Pierre; Chew, Valerie
Abstract:
The nature of the tumour-infiltrating leucocytes (TILs) is known to impact clinical outcome in carcinomas, including hepatocellular carcinoma (HCC). However, the role of tumour-infiltrating B cells (TIBs) remains controversial. Here, we investigate the impact of TIBs and their interaction with T cells on HCC patient prognosis.Tissue samples were obtained from 112 patients with HCC from Singapore, Hong Kong and Zurich and analysed using immunohistochemistry and immunofluorescence. RNA expression...     »
Journal title abbreviation:
Gut
Year:
2017
Journal volume:
66
Journal issue:
2
Pages contribution:
342-351
Language:
eng
Fulltext / DOI:
doi:10.1136/gutjnl-2015-310814
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26669617
Print-ISSN:
0017-5749
TUM Institution:
Institut für Virologie
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