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Title:

Analyses of HBV cccDNA Quantification and Modification.

Document type:
Journal Article
Author(s):
Xia, Yuchen; Stadler, Daniela; Ko, Chunkyu; Protzer, Ulrike
Abstract:
Covalently closed circular DNA (cccDNA) serves as the transcriptional template of hepatitis B virus (HBV) replication in the nucleus of infected cells. It ensures the persistence of HBV even if replication is blocked. Immune-mediated killing of infected hepatocytes, cell division, or cytokine induced non-cytolytic degradation of cccDNA can induce the loss of cccDNA. For studies on HBV control, the analysis of cccDNA integrity and its exact quantification is very important. Here, we describe diff...     »
Journal title abbreviation:
Methods Mol Biol
Year:
2017
Journal volume:
1540
Pages contribution:
59-72
Language:
eng
Fulltext / DOI:
doi:10.1007/978-1-4939-6700-1_6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27975308
Print-ISSN:
1064-3745
TUM Institution:
Institut für Virologie
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