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Titel:

Construction of a hepatitis B virus neutralizing chimeric monoclonal antibody recognizing escape mutants of the viral surface antigen (HBsAg).

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Golsaz-Shirazi, Forough; Amiri, Mohammad Mehdi; Farid, Samira; Bahadori, Motahareh; Bohne, Felix; Altstetter, Sebastian; Wolff, Lisa; Kazemi, Tohid; Khoshnoodi, Jalal; Hojjat-Farsangi, Mohammad; Chudy, Michael; Jeddi-Tehrani, Mahmood; Protzer, Ulrike; Shokri, Fazel
Abstract:
Hepatitis B virus (HBV) infection is a global burden on the health-care system and is considered as the tenth leading cause of death in the world. Over 248 million patients are currently suffering from chronic HBV infection worldwide and annual mortality rate of this infection is 686000. The "a" determinant is a hydrophilic region present in all antigenic subtypes of hepatitis B surface antigen (HBsAg), and antibodies against this region can neutralize the virus and are protective against all su...     »
Zeitschriftentitel:
Antiviral Res
Jahr:
2017
Band / Volume:
144
Seitenangaben Beitrag:
153-163
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.antiviral.2017.06.013
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28641998
Print-ISSN:
0166-3542
TUM Einrichtung:
Institut für Virologie
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