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Titel:

Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Autor(en):
Xia, Yuchen; Carpentier, Arnaud; Cheng, Xiaoming; Block, Peter Daniel; Zhao, Yao; Zhang, Zhensheng; Protzer, Ulrike; Liang, T Jake
Abstract:
One major obstacle of hepatitis B virus (HBV) research is the lack of efficient cell culture system permissive for viral infection and replication. The aim of our study was to establish a robust HBV infection model by using hepatocyte-like cells (HLCs) derived from human pluripotent stem cells.HLCs were differentiated from human embryonic stem cells and induced pluripotent stem cells. Maturation of hepatocyte functions was determined. After HBV infection, total viral DNA, cccDNA, total viral RNA...     »
Zeitschriftentitel:
J Hepatol
Jahr:
2017
Band / Volume:
66
Heft / Issue:
3
Seitenangaben Beitrag:
494-503
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jhep.2016.10.009
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27746336
Print-ISSN:
0168-8278
TUM Einrichtung:
Institut für Virologie
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