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Title:

Targeting Fibroblast Growth Factor Receptor 1 for Treatment of Soft-Tissue Sarcoma.

Document type:
Journal Article
Author(s):
Chudasama, Priya; Renner, Marcus; Straub, Melanie; Mughal, Sadaf S; Hutter, Barbara; Kosaloglu, Zeynep; Schweßinger, Ron; Scheffler, Matthias; Alldinger, Ingo; Schimmack, Simon; Persigehl, Thorsten; Kobe, Carsten; Jäger, Dirk; von Kalle, Christof; Schirmacher, Peter; Beckhaus, Marie-Kristin; Wolf, Stephan; Heining, Christoph; Gröschel, Stefan; Wolf, Jürgen; Brors, Benedikt; Weichert, Wilko; Glimm, Hanno; Scholl, Claudia; Mechtersheimer, Gunhild; Specht, Katja; Fröhling, Stefan
Abstract:
Purpose: Altered FGFR1 signaling has emerged as a therapeutic target in epithelial malignancies. In contrast, the role of FGFR1 in soft-tissue sarcoma (STS) has not been established. Prompted by the detection and subsequent therapeutic inhibition of amplified FGFR1 in a patient with metastatic leiomyosarcoma, we investigated the oncogenic properties of FGFR1 and its potential as a drug target in patients with STS.Experimental Design: The frequency of FGFR1 amplification and overexpression, as as...     »
Journal title abbreviation:
Clin Cancer Res
Year:
2017
Journal volume:
23
Journal issue:
4
Pages contribution:
962-973
Language:
eng
Fulltext / DOI:
doi:10.1158/1078-0432.CCR-16-0860
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27535980
Print-ISSN:
1078-0432
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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