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Title:

Loss of Chromosome 18 in Neuroendocrine Tumors of the Small Intestine: The Enigma Remains.

Document type:
Journal Article; Article
Author(s):
Nieser, Maike; Henopp, Tobias; Brix, Joachim; Stoß, Laura; Sitek, Barbara; Naboulsi, Wael; Anlauf, Martin; Schlitter, Anna M; Klöppel, Günter; Gress, Thomas; Moll, Roland; Bartsch, Detlef K; Heverhagen, Anna E; Knoefel, Wolfram T; Kaemmerer, Daniel; Haybaeck, Johannes; Fend, Falko; Sperveslage, Jan; Sipos, Bence
Abstract:
Neuroendocrine tumors of the small intestine (SI-NETs) exhibit an increasing incidence and high mortality rate. Until now, no fundamental molecular event has been linked to the tumorigenesis and progression of these tumors. Only the loss of chromosome 18 (Chr18) has been shown in up to two thirds of SI-NETs, whereby the significance of this alteration is still not understood. We therefore performed the first comprehensive study to identify Chr18-related events at the genetic, epigenetic and gene...     »
Journal title abbreviation:
Neuroendocrinology
Year:
2017
Journal volume:
104
Journal issue:
3
Pages contribution:
302-312
Language:
eng
Fulltext / DOI:
doi:10.1159/000446917
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27222126
Print-ISSN:
0028-3835
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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