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Titel:

Loss of Chromosome 18 in Neuroendocrine Tumors of the Small Intestine: The Enigma Remains.

Dokumenttyp:
Journal Article; Article
Autor(en):
Nieser, Maike; Henopp, Tobias; Brix, Joachim; Stoß, Laura; Sitek, Barbara; Naboulsi, Wael; Anlauf, Martin; Schlitter, Anna M; Klöppel, Günter; Gress, Thomas; Moll, Roland; Bartsch, Detlef K; Heverhagen, Anna E; Knoefel, Wolfram T; Kaemmerer, Daniel; Haybaeck, Johannes; Fend, Falko; Sperveslage, Jan; Sipos, Bence
Abstract:
Neuroendocrine tumors of the small intestine (SI-NETs) exhibit an increasing incidence and high mortality rate. Until now, no fundamental molecular event has been linked to the tumorigenesis and progression of these tumors. Only the loss of chromosome 18 (Chr18) has been shown in up to two thirds of SI-NETs, whereby the significance of this alteration is still not understood. We therefore performed the first comprehensive study to identify Chr18-related events at the genetic, epigenetic and gene...     »
Zeitschriftentitel:
Neuroendocrinology
Jahr:
2017
Band / Volume:
104
Heft / Issue:
3
Seitenangaben Beitrag:
302-312
Sprache:
eng
Volltext / DOI:
doi:10.1159/000446917
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27222126
Print-ISSN:
0028-3835
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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