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Title:

Overexpression of Insulin-Like Growth Factor-2 in Expanded Endothelial Progenitor Cells Improves Left Ventricular Function in Experimental Myocardial Infarction.

Document type:
Journal Article; Article
Author(s):
Demetz, Gabi; Oostendorp, Robert A J; Boxberg, A Melanie; Sitz, Wibke; Farrell, Eliane; Steppich, Birgit; Steinsiek, Anna-Lena; Rudelius, Martina; Ott, Ilka
Abstract:
Insulin-like growth factors (IGFs) are mediators of growth hormone-induced metabolic and anabolic actions, but also regulate cell growth, differentiation, and apoptosis and show beneficial effects in acute myocardial ischemia. Since endothelial progenitor cells (EPCs) improve myocardial function after acute myocardial infarction, we sought to investigate whether overexpression of IGF-2 in expanded EPCs (eEPCs) further contributes to improvement in left ventricular function after myocardial infar...     »
Journal title abbreviation:
J Vasc Res
Year:
2017
Journal volume:
54
Journal issue:
6
Pages contribution:
321-328
Language:
eng
Fulltext / DOI:
doi:10.1159/000479872
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28950284
Print-ISSN:
1018-1172
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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