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Title:

Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis.

Document type:
Journal Article
Author(s):
Keller, Simone; Kneissl, Julia; Grabher-Meier, Verena; Heindl, Stefan; Hasenauer, Jan; Maier, Dieter; Mattes, Julian; Winter, Peter; Luber, Birgit
Abstract:
Gastric cancers frequently overexpress the epidermal growth factor receptor (EGFR), which has been implicated in pathological processes including tumor cell motility, invasion and metastasis. Targeting EGFR with the inhibitory antibody cetuximab may affect the motile and invasive behavior of tumor cells. Here, we evaluated the effects of EGFR signaling in gastric cancer cell lines to link the phenotypic behavior of the cells with their molecular characteristics.Phenotypic effects were analyzed i...     »
Journal title abbreviation:
BMC Cancer
Year:
2017
Journal volume:
17
Journal issue:
1
Pages contribution:
845
Language:
eng
Fulltext / DOI:
doi:10.1186/s12885-017-3822-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29237412
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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