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Titel:

Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis.

Dokumenttyp:
Journal Article
Autor(en):
Keller, Simone; Kneissl, Julia; Grabher-Meier, Verena; Heindl, Stefan; Hasenauer, Jan; Maier, Dieter; Mattes, Julian; Winter, Peter; Luber, Birgit
Abstract:
Gastric cancers frequently overexpress the epidermal growth factor receptor (EGFR), which has been implicated in pathological processes including tumor cell motility, invasion and metastasis. Targeting EGFR with the inhibitory antibody cetuximab may affect the motile and invasive behavior of tumor cells. Here, we evaluated the effects of EGFR signaling in gastric cancer cell lines to link the phenotypic behavior of the cells with their molecular characteristics.Phenotypic effects were analyzed i...     »
Zeitschriftentitel:
BMC Cancer
Jahr:
2017
Band / Volume:
17
Heft / Issue:
1
Seitenangaben Beitrag:
845
Sprache:
eng
Volltext / DOI:
doi:10.1186/s12885-017-3822-3
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29237412
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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