User: Guest  Login
Title:

Tubular, lactating, and ductal adenomas are devoid of MED12 Exon2 mutations, and ductal adenomas show recurrent mutations in GNAS and the PI3K-AKT pathway.

Document type:
Journal Article
Author(s):
Volckmar, Anna-Lena; Leichsenring, Jonas; Flechtenmacher, Christa; Pfarr, Nicole; Siebolts, Udo; Kirchner, Martina; Budczies, Jan; Bockmayr, Michael; Ridinger, Kathrin; Lorenz, Katja; Herpel, Esther; Noske, Aurelia; Weichert, Wilko; Klauschen, Frederick; Schirmacher, Peter; Penzel, Roland; Endris, Volker; Stenzinger, Albrecht
Abstract:
Adenomas of the breast are rare benign tumors although single cases with malignant behavior have been reported. However, the genetic basis of these tumors is unknown. Employing targeted next generation sequencing of 50 cancer-related genes as well as Sanger sequencing, we profiled a cohort of 18 mammary adenomas comprising 9 ductal, 6 tubular, and 3 lactating adenoma. Missense mutations were detected in 8 of the 18 cases (44%). Specifically, five (56%) ductal adenomas and three (50%) tubular ade...     »
Journal title abbreviation:
Genes Chromosomes Cancer
Year:
2017
Journal volume:
56
Journal issue:
1
Pages contribution:
11-17
Language:
eng
Fulltext / DOI:
doi:10.1002/gcc.22396
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27438523
Print-ISSN:
1045-2257
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
 BibTeX