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Title:

Epithelial NEMO/IKK? limits fibrosis and promotes regeneration during pancreatitis.

Document type:
Journal Article
Author(s):
Chan, Lap Kwan; Gerstenlauer, Melanie; Konukiewitz, Björn; Steiger, Katja; Weichert, Wilko; Wirth, Thomas; Maier, Harald Jakob
Abstract:
Inhibitory ?B kinase (IKK)/nuclear factor ?B (NF-?B) signalling has been implicated in the pathogenesis of pancreatitis, but its precise function has remained controversial. Here, we analyse the contribution of IKK/NF-?B signalling in epithelial cells to the pathogenesis of pancreatitis by targeting the IKK subunit NF-?B essential modulator (NEMO) (IKK?), which is essential for canonical NF-?B activation.Mice with a targeted deletion of NEMO in the pancreas were subjected to caerulein pancreatit...     »
Journal title abbreviation:
Gut
Year:
2017
Journal volume:
66
Journal issue:
11
Pages contribution:
1995-2007
Language:
eng
Fulltext / DOI:
doi:10.1136/gutjnl-2015-311028
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27464707
Print-ISSN:
0017-5749
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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