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Title:

Targeted next-generation sequencing enables reliable detection of HER2 (ERBB2) status in breast cancer and provides ancillary information of clinical relevance.

Document type:
Journal Article
Author(s):
Pfarr, Nicole; Penzel, Roland; Endris, Volker; Lier, Clemens; Flechtenmacher, Christa; Volckmar, Anna-Lena; Kirchner, Martina; Budczies, Jan; Leichsenring, Jonas; Herpel, Esther; Noske, Aurelia; Weichert, Wilko; Schneeweiss, Andreas; Schirmacher, Peter; Sinn, Hans-Peter; Stenzinger, Albrecht
Abstract:
HER2-positive breast cancers are a heterogeneous group of tumors, which share amplification and overexpression of HER2. In routine diagnostics, the HER2 (ERBB2) status is currently assessed by immunohistochemistry (IHC) and in situ hybridization (ISH). Data on targeted next-generation sequencing (NGS) approaches that could be used to determine the HER2 status are sparse. Employing two breast cancer-related gene panels, we performed targeted NGS of 41 FFPE breast cancers for which full pathologic...     »
Journal title abbreviation:
Genes Chromosomes Cancer
Year:
2017
Journal volume:
56
Journal issue:
4
Pages contribution:
255-265
Language:
eng
Fulltext / DOI:
doi:10.1002/gcc.22431
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27792260
Print-ISSN:
1045-2257
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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