Neuropeptide S Receptor Gene Variation Differentially Modulates Fronto-Limbic Effective Connectivity in Childhood and Adolescence.

Domschke, Katharina; Akhrif, Atae; Romanos, Marcel; Bajer, Christina; Mainusch, Margrit; Winkelmann, Juliane; Zimmer, Claus; Neufang, Susanne

doi:10.1093/cercor/bhv259

2017

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Titel:: Neuropeptide S Receptor Gene Variation Differentially Modulates Fronto-Limbic Effective Connectivity in Childhood and Adolescence.
Dokumenttyp:: Journal Article
Autor(en):: Domschke, Katharina; Akhrif, Atae; Romanos, Marcel; Bajer, Christina; Mainusch, Margrit; Winkelmann, Juliane; Zimmer, Claus; Neufang, Susanne
Abstract:: The neuropeptide S (NPS) system contributes to the pathogenesis of anxiety. The more active T allele of the functional rs324981 variant in the neuropeptide S receptor gene (NPSR1) is associated with panic disorder (PD) and distorted cortico-limbic activity during emotion processing in healthy adults and PD patients. This study investigated the influence of NPSR1 genotype on fronto-limbic effective connectivity within the developing brain. Sixty healthy subjects (8-21 years) were examined using an emotional go-nogo task and fMRI. Fronto-limbic connectivity was determined using Dynamic Causal Modeling. In A allele carriers, connectivity between the right middle frontal gyrus (MFG) and the right amygdala was higher in older (>=14 years) than that in younger (<14 years) probands, whereas TT homozygotes >=14 years showed a reduction of fronto-limbic connectivity between the MFG and both the amygdala and the insula. Fronto-limbic connectivity varied between NPSR1 genotypes in the developing brain suggesting a risk-increasing effect of the NPSR1T allele for anxiety-related traits via impaired top-down control of limbic structures emerging during adolescence. Provided robust replication in longitudinal studies, these findings may constitute valuable biomarkers for early targeted prevention of anxiety disorders.
Zeitschriftentitel:: Cereb Cortex
Jahr:: 2017
Band / Volume:: 27
Heft / Issue:: 1
Seitenangaben Beitrag:: 554-566
Sprache:: eng
Volltext / DOI:: doi:10.1093/cercor/bhv259
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/26503268
Print-ISSN:: 1047-3211
TUM Einrichtung:: Fachgebiet Neuroradiologie (Prof. Zimmer); Lehrstuhl für Neurogenetik (Prof. Winkelmann)
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