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Title:

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Niki?, Ivana; Merkler, Doron; Sorbara, Catherine; Brinkoetter, Mary; Kreutzfeldt, Mario; Bareyre, Florence M; Brück, Wolfgang; Bishop, Derron; Misgeld, Thomas; Kerschensteiner, Martin
Abstract:
In multiple sclerosis, a common inflammatory disease of the central nervous system, immune-mediated axon damage is responsible for permanent neurological deficits. How axon damage is initiated is not known. Here we use in vivo imaging to identify a previously undescribed variant of axon damage in a mouse model of multiple sclerosis. This process, termed 'focal axonal degeneration' (FAD), is characterized by sequential stages, beginning with focal swellings and progressing to axon fragmentation....     »
Journal title abbreviation:
Nat Med
Year:
2011
Journal volume:
17
Journal issue:
4
Pages contribution:
495-9
Language:
eng
Fulltext / DOI:
doi:10.1038/nm.2324
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21441916
Print-ISSN:
1078-8956
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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