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Titel:

Specific and redundant functions of histone deacetylases in regulation of cell cycle and apoptosis.

Dokumenttyp:
Journal Article
Autor(en):
Zhu, P; Huber, E; Kiefer, F; Göttlicher, M
Abstract:
Inappropriate control of expression of genetic information is the cause of many forms of cancer. Aberrant transcriptional repression by recruitment of histone deacetylases (HDACs) is a key step in pathogenesis of myeloid leukemia. We recently reported that development of colonic cancer involves alterations in the transcriptional repression machinery by increased expression of HDAC2 upon loss of the APC tumor suppressor. Increased expression of HDAC2 is essential for prevention of apoptosis of HT...     »
Zeitschriftentitel:
Cell Cycle
Jahr:
2004
Band / Volume:
3
Heft / Issue:
10
Seitenangaben Beitrag:
1240-2
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15477762
Print-ISSN:
1538-4101
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
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