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Title:

Control of intestinal motility by the Ca(v)1.2 L-type calcium channel in mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Wegener, JW; Schulla, V; Koller, A; Klugbauer, N; Feil, R; Hofmann, F
Abstract:
The Ca(v)1.2 L-type Ca2+ channel is the dominant voltage-activated Ca2+ channel in heart and smooth muscle. The functional significance of this channel was studied in intestinal smooth muscle from mice carrying a smooth muscle-specific, conditional inactivation of the Ca(v)1.2 gene (Ca(v)1.2SMACKO mice). Inactivation was complete within 4 wk after tamoxifen treatment and confirmed by RT-PCR, Western blot and functional analysis. Ca(v)1.2SMACKO mice show reduced feces excretion, absence of rhythm...     »
Journal title abbreviation:
FASEB J
Year:
2006
Journal volume:
20
Journal issue:
8
Pages contribution:
1260-2
Language:
eng
Fulltext / DOI:
doi:10.1096/fj.05-5292fje
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16636102
Print-ISSN:
0892-6638
TUM Institution:
Institut für Pharmakologie und Toxikologie
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