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Titel:

Investigation of genetic variants of genes of the hemochromatosis pathway and their role in breast cancer.

Dokumenttyp:
Journal Article
Autor(en):
Abraham, BK; Justenhoven, C; Pesch, B; Harth, V; Weirich, G; Baisch, C; Rabstein, S; Ko, YD; Bruning, T; Fischer, HP; Haas, S; Brod, S; Oberkanins, C; Hamann, U; Brauch, H
Abstract:
Iron overload has been noticed as a feature of human breast cancer. Cellular iron uptake is regulated by the hemochromatosis and transferrin receptor system, mutations of which cause the iron storage disease hereditary hemochromatosis. To understand the role of hemochromatosis and transferrin receptor system mutations in breast cancer, we analyzed 19 sequence variations at HFE, TFR1, TFR2, and FPN1 and compared genotype frequencies between cases and controls in a German population. There were 68...     »
Zeitschriftentitel:
Cancer Epidemiol Biomarkers Prev
Jahr:
2005
Band / Volume:
14
Heft / Issue:
5
Seitenangaben Beitrag:
1102-7
Sprache:
eng
Volltext / DOI:
doi:10.1158/1055-9965.EPI-05-0013
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15894659
Print-ISSN:
1055-9965
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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