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Title:

Assembly of the postsynaptic membrane at the neuromuscular junction: paradigm lost.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review; Review
Author(s):
Kummer, TT; Misgeld, T; Sanes, JR
Abstract:
Studies of the vertebrate skeletal neuromuscular junction led to an influential model of how neurotransmitter receptors accumulate in the postsynaptic membrane. In this model, motor axons organize postsynaptic development by secreting neuregulin to induce acetylcholine receptor gene transcription in specialized subsynaptic nuclei, agrin to cluster diffuse receptors in the postsynaptic membrane, and acetylcholine to evoke electrical activity that promotes synaptic maturation. However, new studies...     »
Journal title abbreviation:
Curr Opin Neurobiol
Year:
2006
Journal volume:
16
Journal issue:
1
Pages contribution:
74-82
Language:
eng
Fulltext / DOI:
doi:10.1016/j.conb.2005.12.003
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16386415
Print-ISSN:
0959-4388
TUM Institution:
Institut für Neurowissenschaften
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