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Title:

Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency.

Document type:
Journal Article; Article
Author(s):
Sausbier, M; Hu, H; Arntz, C; Feil, S; Kamm, S; Adelsberger, H; Sausbier, U; Sailer, CA; Feil, R; Hofmann, F; Korth, M; Shipston, MJ; Knaus, HG; Wolfer, DP; Pedroarena, CM; Storm, JF; Ruth, P
Abstract:
Malfunctions of potassium channels are increasingly implicated as causes of neurological disorders. However, the functional roles of the large-conductance voltage- and Ca(2+)-activated K(+) channel (BK channel), a unique calcium, and voltage-activated potassium channel type have remained elusive. Here we report that mice lacking BK channels (BK(-/-)) show cerebellar dysfunction in the form of abnormal conditioned eye-blink reflex, abnormal locomotion and pronounced deficiency in motor coordinati...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2004
Journal volume:
101
Journal issue:
25
Pages contribution:
9474-8
Language:
eng
Fulltext / DOI:
doi:10.1073/pnas.0401702101
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15194823
Print-ISSN:
0027-8424
TUM Institution:
Institut für Neurowissenschaften; Institut für Pharmakologie und Toxikologie
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