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Title:

Distinct roles of Galpha(q) and Galpha11 for Purkinje cell signaling and motor behavior.

Document type:
Journal Article; Article
Author(s):
Hartmann, J; Blum, R; Kovalchuk, Y; Adelsberger, H; Kuner, R; Durand, GM; Miyata, M; Kano, M; Offermanns, S; Konnerth, A
Abstract:
G-protein-coupled metabotropic glutamate group I receptors (mGluR1s) mediate synaptic transmission and plasticity in Purkinje cells and, therefore, critically determine cerebellar motor control and learning. Purkinje cells express two members of the G-protein G(q) family, namely G(q) and G11. Although in vitro coexpression of mGluR1 with either Galpha11 or Galpha(q) produces equally well functioning signaling cascades, Galpha(q)- and Galpha11-deficient mice exhibit distinct alterations in motor...     »
Journal title abbreviation:
J Neurosci
Year:
2004
Journal volume:
24
Journal issue:
22
Pages contribution:
5119-30
Language:
eng
Fulltext / DOI:
doi:10.1523/JNEUROSCI.4193-03.2004
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15175381
Print-ISSN:
0270-6474
TUM Institution:
Institut für Neurowissenschaften
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