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Titel:

Neurotrophin action on a rapid timescale.

Dokumenttyp:
Journal Article; Review; Review
Autor(en):
Kovalchuk, Y; Holthoff, K; Konnerth, A
Abstract:
Mechanisms underlying the fast action of neurotrophins include intracellular Ca(2+) signaling, neuronal excitation, augmentation of synaptic excitation by modulation of N-methyl-d-aspartate receptor activity and control of synaptic inhibition through the regulation of the K(+)-Cl(-) cotransporter KCC2. The fastest action of brain-derived neurotrophic factor and neurotrophin-4/5 occurs within milliseconds, and involves activation of TrkB and the opening of the Na(+) channel Na(v)1.9. Through thes...     »
Zeitschriftentitel:
Curr Opin Neurobiol
Jahr:
2004
Band / Volume:
14
Heft / Issue:
5
Seitenangaben Beitrag:
558-63
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.conb.2004.08.014
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15464888
Print-ISSN:
0959-4388
TUM Einrichtung:
Institut für Neurowissenschaften
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