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Titel:

Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2.

Dokumenttyp:
Journal Article; Article
Autor(en):
Ludwig, A; Budde, T; Stieber, J; Moosmang, S; Wahl, C; Holthoff, K; Langebartels, A; Wotjak, C; Munsch, T; Zong, X; Feil, S; Feil, R; Lancel, M; Chien, KR; Konnerth, A; Pape, HC; Biel, M; Hofmann, F
Abstract:
Hyperpolarization-activated cation (HCN) channels are believed to be involved in the generation of cardiac pacemaker depolarizations as well as in the control of neuronal excitability and plasticity. The contributions of the four individual HCN channel isoforms (HCN1-4) to these diverse functions are not known. Here we show that HCN2-deficient mice exhibit spontaneous absence seizures. The thalamocortical relay neurons of these mice displayed a near complete loss of the HCN current, resulting in...     »
Zeitschriftentitel:
EMBO J
Jahr:
2003
Band / Volume:
22
Heft / Issue:
2
Seitenangaben Beitrag:
216-24
Sprache:
eng
Volltext / DOI:
doi:10.1093/emboj/cdg032
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12514127
Print-ISSN:
0261-4189
TUM Einrichtung:
Institut für Neurowissenschaften; Institut für Pharmakologie und Toxikologie
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