User: Guest  Login
Less Searchfields
Simple search
Title:

Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordination.

Document type:
Journal Article; Article
Author(s):
Barski, JJ; Hartmann, J; Rose, CR; Hoebeek, F; Mörl, K; Noll-Hussong, M; De Zeeuw, CI; Konnerth, A; Meyer, M
Abstract:
Long-term depression (LTD) of Purkinje cell-parallel fiber synaptic transmission is a critical determinant of normal cerebellar function. Impairment of LTD through, for example, disruption of the metabotropic glutamate receptor-IP3-calcium signaling cascade in mutant mice results in severe deficits of both synaptic transmission and cerebellar motor control. Here, we demonstrate that selective genetic deletion of the calcium-binding protein calbindin D-28k (calbindin) from cerebellar Purkinje cel...     »
Journal title abbreviation:
J Neurosci
Year:
2003
Journal volume:
23
Journal issue:
8
Pages contribution:
3469-77
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12716955
Print-ISSN:
0270-6474
TUM Institution:
Institut für Neurowissenschaften
 BibTeX