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Title:

Use of knockout mice reveals involvement of M2-muscarinic receptors in control of the kinetics of acetylcholine release.

Document type:
Journal Article; Article
Author(s):
Slutsky, I; Wess, J; Gomeza, J; Dudel, J; Parnas, I; Parnas, H
Abstract:
We have previously suggested that presynaptic M(2)-muscarinic receptors (M(2)R) are involved in the control of the time course of evoked acetylcholine release in the frog neuromuscular junction. The availability of knockout mice lacking functional M(2)R (M(2)-KO) enabled us to address this issue in a more direct way. Using the phrenic diaphragm preparation, we show that in wild-type (WT) mice experimental manipulations known to affect Ca(2+) entry and removal, greatly affected the amount of acet...     »
Journal title abbreviation:
J Neurophysiol
Year:
2003
Journal volume:
89
Journal issue:
4
Pages contribution:
1954-67
Language:
eng
Fulltext / DOI:
doi:10.1152/jn.00668.2002
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12686574
Print-ISSN:
0022-3077
TUM Institution:
Institut für Neurowissenschaften
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