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Titel:

Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordination.

Dokumenttyp:
Journal Article; Article
Autor(en):
Barski, JJ; Hartmann, J; Rose, CR; Hoebeek, F; Mörl, K; Noll-Hussong, M; De Zeeuw, CI; Konnerth, A; Meyer, M
Abstract:
Long-term depression (LTD) of Purkinje cell-parallel fiber synaptic transmission is a critical determinant of normal cerebellar function. Impairment of LTD through, for example, disruption of the metabotropic glutamate receptor-IP3-calcium signaling cascade in mutant mice results in severe deficits of both synaptic transmission and cerebellar motor control. Here, we demonstrate that selective genetic deletion of the calcium-binding protein calbindin D-28k (calbindin) from cerebellar Purkinje cel...     »
Zeitschriftentitel:
J Neurosci
Jahr:
2003
Band / Volume:
23
Heft / Issue:
8
Seitenangaben Beitrag:
3469-77
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12716955
Print-ISSN:
0270-6474
TUM Einrichtung:
Institut für Neurowissenschaften
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