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- Titel:
Blood-CSF barrier integrity in multiple sclerosis.
- Dokumenttyp:
- Journal Article; Article
- Autor(en):
- Liebsch, R; Kornhuber, ME; Dietl, D; Gräfin von Einsiedel, H; Conrad, B
- Abstract:
- INTRODUCTION: In about 20% of MS patients an increased CSF/serum albumin quotient (QAlb) has been observed. The reason for this blood-CSF barrier dysfunction is yet unclear. SUBJECTS AND METHODS: QAlb values from 48 MS patients in relapse were correlated with parameters of active CNS lesions as measured by gadolinium-DTPA MRIs. QAlb values from 20 MS patients without relapse served as controls. RESULTS: Mean QAlb values (x 10(3) of a group with spinal cord lesions (7.6 +/- 3.6; n = 16) differed significantly from those of a control group (4.6 +/- 1.5; n = 20; p < 0.005) as well as from those of a group with supratentorial lesions (5.0 +/- 1.8; n = 18; p < 0.05), and were higher than those of a group with infratentorial lesions (5.8 +/- 2.8; n = 14). QAlb values of patients with a spinal lesion tended to decrease with increasing time intervals between onset of relapse and lumbar puncture. CONCLUSION: The data is in consent with the present knowledge on flow dynamics of both extracellular fluid and CSF. As a clinical consequence, increased QAlb values in MS patients may hint at an active spinal or, less likely, infratentorial lesion.
- Zeitschriftentitel:
- Acta Neurol Scand
- Jahr:
- 1996
- Band / Volume:
- 94
- Heft / Issue:
- 6
- Seitenangaben Beitrag:
- 404-10
- Sprache:
- eng
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/9017028
- Print-ISSN:
- 0001-6314
- TUM Einrichtung:
- Neurologische Klinik und Poliklinik
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