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Title:

Apoptosis and treatment of chronic allograft nephropathy with everolimus.

Document type:
Journal Article; Article
Author(s):
Lutz, J; Zou, H; Liu, S; Antus, B; Heemann, U
Abstract:
BACKGROUND: Chronic allograft nephropathy (CAN) is responsible for most cases of late kidney allograft loss. However, no effective treatment is available so far. Everolimus (RAD) (40-O [2-hydroxyethyl] rapamycin) is a new immunosuppressive agent with antiproliferative and apoptosis-enhancing effects. We asked whether everolimus can ameliorate CAN even at advanced stages, whether everolimus treatment affects the level of growth factor mRNA, and whether everolimus treatment affects the number of a...     »
Journal title abbreviation:
Transplantation
Year:
2003
Journal volume:
76
Journal issue:
3
Pages contribution:
508-15
Language:
eng
Fulltext / DOI:
doi:10.1097/01.TP.0000074722.79186.A9
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12923436
Print-ISSN:
0041-1337
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann)
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