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Title:

SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Neumann, J; Bahr, F; Horst, D; Kriegl, L; Engel, J; Luque, RM; Gerhard, M; Kirchner, T; Jung, A
Abstract:
The transcription factor SOX2, which is involved in the induction of pluripotent stem cells and contributes to colorectal carcinogenesis, is associated with a poor prognosis in colon cancer (CC). Furthermore, SOX2 is a repressor of the transcriptional activity of ?-catenin in vitro. Since the majority of CC develop via an activation of the Wnt/?-catenin signalling pathway, indicated by nuclear expression of ?-catenin, we wanted to investigate the expression patterns of SOX2 and ?-catenin and cor...     »
Journal title abbreviation:
BMC Cancer
Year:
2011
Journal volume:
11
Pages contribution:
518
Language:
eng
Fulltext / DOI:
doi:10.1186/1471-2407-11-518
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22168803
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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