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Titel:

CpG motif-independent activation of TLR9 upon endosomal translocation of "natural" phosphodiester DNA.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Yasuda, K; Rutz, M; Schlatter, B; Metzger, J; Luppa, PB; Schmitz, F; Haas, T; Heit, A; Bauer, S; Wagner, H
Abstract:
Endosomally translocated host (self) DNA activates Toll-like receptor 9 (TLR9), while extracellular self-DNA does not. This inconsistency reflects poor endosomal DNA translocation but also implies that host DNA contains DNA sequences that function as ligands for TLR9. Herein we report that contrary to phosphorothioate (PS)-stabilized oligonucleotides (ODN), "natural" phosphodiester (PD) ODN lacking CpG motifs activate TLR9. CpG motif-independent TLR9 activation of Flt3-L-induced dendritic cells...     »
Zeitschriftentitel:
Eur J Immunol
Jahr:
2006
Band / Volume:
36
Heft / Issue:
2
Seitenangaben Beitrag:
431-6
Sprache:
eng
Volltext / DOI:
doi:10.1002/eji.200535210
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16421948
Print-ISSN:
0014-2980
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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