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Title:

Partial tyrosinase-specific self tolerance by HLA-A*0201-restricted cytotoxic T lymphocytes in mice and man.

Document type:
Journal Article
Author(s):
Lotz, C; Ferreira, EA; Drexler, I; Mutallib, SA; Huber, C; Sutter, G; Theobald, M
Abstract:
The human tyrosinase (hTyr) (369-377) cytotoxic T lymphocyte (CTL) epitope is presented by malignant melanoma and various nontransformed cells in association with human leukocyte antigen (HLA)-A*0201 (A2.1) and used for vaccination-based immunotherapy of melanoma patients. Its mouse homologue, mTyr (369-377), is naturally processed and bound by A2.1 with equivalent efficacy and thus enabled us to explore the effect of self tolerance on Tyr-specific T cells in different lines of A2.1 transgenic (...     »
Journal title abbreviation:
Int J Cancer
Year:
2004
Journal volume:
108
Journal issue:
4
Pages contribution:
571-9
Language:
eng
Fulltext / DOI:
doi:10.1002/ijc.11602
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/14696122
Print-ISSN:
0020-7136
TUM Institution:
Institut für Virologie
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