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Titel:

Melanoma-reactive class I-restricted cytotoxic T cell clones are stimulated by dendritic cells loaded with synthetic peptides, but fail to respond to dendritic cells pulsed with melanoma-derived heat shock proteins in vitro.

Dokumenttyp:
Journal Article; Article
Autor(en):
Fleischer, K; Schmidt, B; Kastenmuller, W; Busch, DH; Drexler, I; Sutter, G; Heike, M; Peschel, C; Bernhard, H
Abstract:
Immunization with heat shock proteins (hsp) isolated from cancer cells has been shown to induce a protective antitumor response. The mechanism of hsp-dependent cellular immunity has been attributed to a variety of immunological activities mediated by hsp. Hsp have been shown to bind antigenic peptides, trim the bound peptides by intrinsic enzymatic activity, improve endocytosis of the chaperoned peptides by APCs, and enhance the ability of APCs to stimulate peptide-specific T cells. We have inve...     »
Zeitschriftentitel:
J Immunol
Jahr:
2004
Band / Volume:
172
Heft / Issue:
1
Seitenangaben Beitrag:
162-9
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14688322
Print-ISSN:
0022-1767
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Virologie
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