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Title:

IKK- and NF-?B-mediated functions in carcinogenesis.

Document type:
Journal Article; Review; Book Chapter; Review
Author(s):
Arkan, MC; Greten, FR
Abstract:
Since the initial cloning of RelA and its close relationship to c-Rel, the cellular homolog of the viral oncoprotein v-Rel, the nuclear factor ?B (NF-?B) signaling pathway and its upstream activating kinase complex (I?B-kinase) have been suspected to play a major role in tumorigenesis. This was further corroborated by the discovery of oncogenic mutations in NF-?B proteins in certain lymphoid malignancies and the notion that NF-?B is persistently activated in a large variety of solid tumors. With...     »
Journal title abbreviation:
Curr Top Microbiol Immunol
Year:
2011
Journal volume:
349
Pages contribution:
159-69
Language:
eng
Fulltext / DOI:
doi:10.1007/82_2010_97
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20845109
Print-ISSN:
0070-217X
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Roman Herzog Comprehensive Cancer Center
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