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Titel:

Mechanisms of everolimus-induced glomerulosclerosis after glomerular injury in the rat.

Dokumenttyp:
Journal Article
Autor(en):
Daniel, C; Renders, L; Amann, K; Schulze-Lohoff, E; Hauser, IA; Hugo, C
Abstract:
Despite the lack of nephrotoxicity, adverse effects of the new antiproliferative immunosuppressant everolimus have been reported. By varying time point and dose of everolimus treatment as well as the degree of glomerular injury, the specific conditions and potential mechanisms leading to adverse actions in the anti-Thy1 model have been determined. Only the combination of early and high-dose everolimus treatment (1-3 mg/kg bw) with a severe glomerular lesion ('full-dose' anti-Thy1 model) caused a...     »
Zeitschriftentitel:
Am J Transplant
Jahr:
2005
Band / Volume:
5
Heft / Issue:
12
Seitenangaben Beitrag:
2849-61
Volltext / DOI:
doi:10.1111/j.1600-6143.2005.01120.x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16302997
Print-ISSN:
1600-6135
TUM Einrichtung:
Fachgebiet Nephrologie (Prof. Heemann)
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