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Title:

Human papillomavirus type 16 L1 capsomeres induce L1-specific cytotoxic T lymphocytes and tumor regression in C57BL/6 mice.

Document type:
Journal Article
Author(s):
Ohlschläger, P; Osen, W; Dell, K; Faath, S; Garcea, RL; Jochmus, I; Muller, M; Pawlita, M; Schäfer, K; Sehr, P; Staib, C; Sutter, G; Gissmann, L
Abstract:
We analyzed capsomeres of human papillomavirus type 16 (HPV16) consisting of the L1 major structural protein for their ability to trigger a cytotoxic T-cell (CTL) response. To this end, we immunized C57BL/6 mice and used the L1(165-173) peptide for ex vivo restimulation of splenocytes prior to analysis ((51)Cr release assay and enzyme-linked immunospot assay [ELISPOT]). This peptide was identified in this study as a D(b)-restricted naturally processed CTL epitope by HPV16 L1 sequence analysis, m...     »
Journal title abbreviation:
J Virol
Year:
2003
Journal volume:
77
Journal issue:
8
Pages contribution:
4635-45
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12663770
Print-ISSN:
0022-538X
TUM Institution:
Institut für Virologie
 BibTeX