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Titel:

Analysis of nuclear targeting activities of transport signals in the human immunodeficiency virus Rev protein.

Dokumenttyp:
Journal Article
Autor(en):
Demart, S; Ceccherini-Silberstein, F; Schlicht, S; Walcher, S; Wolff, H; Neumann, M; Erfle, V; Brack-Werner, R
Abstract:
The human immunodeficiency Rev protein shuttles between the nucleus and cytoplasm, while accumulating to high levels in the nucleus. Rev has a nuclear localization signal (NLS; AA 35-50) with an arginine-rich motif (ARM) that interacts with importin beta and a leucine-rich nuclear export signal (NES; AA 75-84) recognized by CRM1/exportin 1. Here we explore nuclear targeting activities of the transport signals of Rev. GFP tagging and quantitative fluorescence microscopy were used to study the l...     »
Zeitschriftentitel:
Exp Cell Res
Jahr:
2003
Band / Volume:
291
Heft / Issue:
2
Seitenangaben Beitrag:
484-501
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14644169
Print-ISSN:
0014-4827
TUM Einrichtung:
Institut für Virologie
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