IL-6 levels predict disease variant and extent of organ involvement in patients with mastocytosis.

Brockow, K; Akin, C; Huber, M; METCALFE, DD

doi:10.1016/j.clim.2005.01.011

journal article

Titel:: IL-6 levels predict disease variant and extent of organ involvement in patients with mastocytosis.
Dokumenttyp:: Journal Article; Article
Autor(en):: Brockow, K; Akin, C; Huber, M; METCALFE, DD
Abstract:: Mastocytosis is often associated with organ involvement and hematological disorders. Patients may also exhibit elevated levels of plasma IL-6. To gain insight into the relevance of this observation, we correlated plasma levels of IL-6 and soluble IL-6 receptor (sIL-6R) with multiple disease parameters in 29 patients with mastocytosis. Mean plasma IL-6 levels were elevated in patients compared to healthy controls (P < 0.0001). Disease category significantly correlated with plasma IL-6 levels, as did severity of bone marrow pathology, organomegaly, and extent of skin involvement. In plasma, there was a positive correlation of IL-6 to total tryptase, alkaline phosphatase, IgM, white blood cell count, prothrombin time, partial thromboplastin time, and neutrophil numbers. There was an inverse correlation to hemoglobin. sIL-6R levels were not elevated. These observations demonstrate that IL-6 is a useful surrogate marker of severity of hematologic disease and suggest that IL-6 contributes to pathology.
Zeitschriftentitel:: Clin Immunol
Jahr:: 2005
Band / Volume:: 115
Heft / Issue:: 2
Seitenangaben Beitrag:: 216-23
Sprache:: eng
Volltext / DOI:: doi:10.1016/j.clim.2005.01.011
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/15885646
Print-ISSN:: 1521-6616
TUM Einrichtung:: Klinik und Poliklinik für Dermatologie und Allergologie
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Dermatologie und Allergologie (Prof. Biedermann)2005