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Document type:
journal article 
Author(s):
Collin, N; Guérin, JL; Drexler, I; Blanié, S; Gelfi, J; Boullier, S; Foucras, G; Sutter, G; Messud-Petit, F 
Title:
The poxviral scrapin MV-LAP requires a myxoma viral infection context to efficiently downregulate MHC-I molecules. 
Abstract:
Downregulation of MHC class I molecules is a strategy developed by some viruses to escape cellular immune responses. Myxoma virus (MV), a poxvirus causing rabbit myxomatosis, encodes MV-LAP that is known to increase MHC-I endocytosis and degradation through a C(4)HC(3) motif critical for an E3 ubiquitin ligase activity. Here, we performed a functional mapping of MV-LAP and showed that not only the C(4)HC(3) motif is necessary for a marked downregulation of MHC-I but also a conserved region in th...    »
 
Journal title abbreviation:
Virology 
Year:
2005 
Journal volume:
343 
Journal issue:
Pages contribution:
171-8 
Language:
eng 
Print-ISSN:
0042-6822 
TUM Institution:
Institut für Virologie