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Titel:

Artificial-infection protocols allow immunodetection of novel Borrelia burgdorferi antigens suitable as vaccine candidates against Lyme disease.

Dokumenttyp:
Journal Article
Autor(en):
Wallich, R; Jahraus, O; Stehle, T; Tran, TT; Brenner, C; Hofmann, H; Gern, L; Simon, MM
Abstract:
Vaccination with recombinant outer surface protein A (OspA) from Borrelia burgdorferi provides excellent antibody-mediated protection against challenge with the pathogen in animal models and in humans. However, the bactericidal antibodies are ineffective in the reservoir host, since OspA is expressed by spirochetes only in the vector, but rarely, if at all, in mammals. Using an artificially generated immune serum (anti-10(8) spirochetes) with high protective potential for prophylactic and therap...     »
Zeitschriftentitel:
Eur J Immunol
Jahr:
2003
Band / Volume:
33
Heft / Issue:
3
Seitenangaben Beitrag:
708-19
Sprache:
eng
Volltext / DOI:
doi:10.1002/eji.200323620
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12616491
Print-ISSN:
0014-2980
TUM Einrichtung:
Klinik und Poliklinik für Dermatologie und Allergologie
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