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Title:

Toll-like receptor expression in human keratinocytes: nuclear factor kappaB controlled gene activation by Staphylococcus aureus is toll-like receptor 2 but not toll-like receptor 4 or platelet activating factor receptor dependent.

Document type:
Journal Article; Article
Author(s):
Mempel, M; Voelcker, V; Köllisch, G; Plank, C; Rad, R; Gerhard, M; Schnopp, C; Fraunberger, P; Walli, AK; Ring, J; Abeck, D; Ollert, M
Abstract:
Cultured primary human keratinocytes were screened for their expression of various members of the toll-like receptor (TLR) family. Keratinocytes were found to constitutively express TLR1, TLR2, TLR3, TLR5, and TLR9 but not TLR4, TLR6, TLR7, TLR8, or TLR10 as shown by polymerase chain reaction analysis. The expression of the crucial receptor for signaling of staphylococcal compounds TLR2 was also confirmed by immunohistochemistry, in contrast to TLR4, which showed a negative staining pattern. Nex...     »
Journal title abbreviation:
J Invest Dermatol
Year:
2003
Journal volume:
121
Journal issue:
6
Pages contribution:
1389-96
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/14675188
Print-ISSN:
0022-202X
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Dermatologie und Allergologie
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