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Title:

Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Wingender, G; Garbi, N; Schumak, B; Jüngerkes, F; Endl, E; von Bubnoff, D; Steitz, J; Striegler, J; Moldenhauer, G; Tüting, T; Heit, A; Huster, KM; Takikawa, O; Akira, S; Busch, DH; Wagner, H; Hämmerling, GJ; Knolle, PA; Limmer, A
Abstract:
CpG-rich oligonucleotides (CpG-ODN) bind to Toll-like receptor 9 (TLR9) and are used as powerful adjuvants for vaccination. Here we report that CpG-ODN not only act as immune stimulatory agents but can also induce strong immune suppression depending on the anatomical location of application. In agreement with the adjuvant effect, subcutaneous application of antigen plus CpG-ODN resulted in antigen-specific T cell activation in local lymph nodes. In contrast, systemic application of CpG-ODN resul...     »
Journal title abbreviation:
Eur J Immunol
Year:
2006
Journal volume:
36
Journal issue:
1
Pages contribution:
12-20
Language:
eng
Fulltext / DOI:
doi:10.1002/eji.200535602
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16323249
Print-ISSN:
0014-2980
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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