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Title:

Mycobacterium tuberculosis regulates CD1 antigen presentation pathways through TLR-2.

Document type:
Journal Article
Author(s):
Roura-Mir, C; Wang, L; Cheng, TY; Matsunaga, I; Dascher, CC; Peng, SL; Fenton, MJ; Kirschning, C; Moody, DB
Abstract:
Mycobacterium tuberculosis remains a major pathogen of worldwide importance, which releases lipid Ags that are presented to human T cells during the course of tuberculosis infections. Here we report that cellular infection with live M. tuberculosis or exposure to mycobacterial cell wall products converted CD1- myeloid precursors into competent APCs that expressed group 1 CD1 proteins (CD1a, CD1b, and CD1c). The appearance of group 1 CD1 proteins at the surface of infected or activated cells occu...     »
Journal title abbreviation:
J Immunol
Year:
2005
Journal volume:
175
Journal issue:
3
Pages contribution:
1758-66
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16034117
Print-ISSN:
0022-1767
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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