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Titel:

Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.

Dokumenttyp:
Journal Article
Autor(en):
Vollmer, J; Tluk, S; Schmitz, C; Hamm, S; Jurk, M; Forsbach, A; Akira, S; Kelly, KM; Reeves, WH; Bauer, S; Krieg, AM
Abstract:
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies to certain cellular macromolecules, such as the small nuclear ribonucleoprotein particles (snRNPs), which had been considered to be passive targets of the autoimmune response. SLE is also characterized by the increased expression of type I interferon (IFN), which appears to be associated with the development and severity of disease. Here, we show that specific, highly conserved RNA seque...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2005
Band / Volume:
202
Heft / Issue:
11
Seitenangaben Beitrag:
1575-85
Sprache:
eng
Volltext / DOI:
doi:10.1084/jem.20051696
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16330816
Print-ISSN:
0022-1007
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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