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Titel:

Enhancement of death-receptor induced caspase-8-activation in the death-inducing signalling complex by uncoupling of oxidative phosphorylation.

Dokumenttyp:
Journal Article
Autor(en):
Vier, J; Gerhard, M; Wagner, H; Häcker, G
Abstract:
Signalling through the death receptor CD95 induces apoptosis by formation of a signalling complex at the cell membrane and subsequent caspase-8 and caspase-3-activation. Treatment of Jurkat T cells with protonophores across the mitochondrial membrane such as 2,4-dinitrophenol (DNP) enhances the death-inducing capacity of CD95. In this study, we show that this enhancement is due to the specific acceleration of caspase-8-processing and activation at the CD95-receptor. DNP-treatment did not affect...     »
Zeitschriftentitel:
Mol Immunol
Jahr:
2004
Band / Volume:
40
Heft / Issue:
10
Seitenangaben Beitrag:
661-70
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14644092
Print-ISSN:
0161-5890
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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