User: Guest  Login
Title:

Synergistic effect of Helicobacter pylori virulence factors and interleukin-1 polymorphisms for the development of severe histological changes in the gastric mucosa.

Document type:
Journal Article
Author(s):
Rad, R; Prinz, C; Neu, B; Neuhofer, M; Zeitner, M; Voland, P; Becker, I; Schepp, W; Gerhard, M
Abstract:
Polymorphisms of the IL-1B and IL-1RN genes (which encode interleukin [IL]-1beta and IL-1 receptor antagonist, respectively) have been associated with hypochlorhydria and gastric cancer. We investigated the influence of bacterial virulence factors and host IL-1 polymorphisms on the development of histologic abnormalities in 210 Helicobacter pylori-infected patients with chronic gastritis. cagA(+)/vacAs1(+) H. pylori strains were associated with intestinal metaplasia (IM), atrophic gastritis (AG)...     »
Journal title abbreviation:
J Infect Dis
Year:
2003
Journal volume:
188
Journal issue:
2
Pages contribution:
272-81
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12854083
Print-ISSN:
0022-1899
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
 BibTeX