User: Guest  Login
Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Author(s):
Williams, Philip R; Marincu, Bogdan-Nicolae; Sorbara, Catherine D; Mahler, Christoph F; Schumacher, Adrian-Minh; Griesbeck, Oliver; Kerschensteiner, Martin; Misgeld, Thomas 
Title:
A recoverable state of axon injury persists for hours after spinal cord contusion in vivo. 
Abstract:
Therapeutic strategies for spinal cord injury (SCI) commonly focus on regenerating disconnected axons. An alternative approach would be to maintain continuity of damaged axons, especially after contusion. The viability of such neuropreservative strategies depends on the degree to which initially injured axons can recover. Here we use morphological and molecular in vivo imaging after contusion SCI in mice to show that injured axons persist in a metastable state for hours. Intra-axonal calcium dyn...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2014 
Journal volume:
Pages contribution:
5683 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
2041-1723 
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)