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Titel:

Engineering of bacteria for the visualization of targeted delivery of a cytolytic anticancer agent.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Jiang, Sheng-Nan; Park, Seung-Hwan; Lee, Hee Jung; Zheng, Jin Hai; Kim, Hyung-Seok; Bom, Hee-Seung; Hong, Yeongjin; Szardenings, Michael; Shin, Myung Geun; Kim, Sun-Chang; Ntziachristos, Vasilis; Choy, Hyon E; Min, Jung-Joon
Abstract:
A number of recent reports have demonstrated that attenuated Salmonella typhimurium are capable of targeting both primary and metastatic tumors. The use of bacteria as a vehicle for the delivery of anticancer drugs requires a mechanism that precisely regulates and visualizes gene expression to ensure the appropriate timing and location of drug production. To integrate these functions into bacteria, we used a repressor-regulated tetracycline efflux system, in which the expression of a therapeutic...     »
Zeitschriftentitel:
Mol Ther
Jahr:
2013
Band / Volume:
21
Heft / Issue:
11
Seitenangaben Beitrag:
1985-95
Sprache:
eng
Volltext / DOI:
doi:10.1038/mt.2013.183
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23922014
Print-ISSN:
1525-0016
TUM Einrichtung:
Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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